diff --git a/CHANGELOG.md b/CHANGELOG.md
index 54da48d..03decdc 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -5,6 +5,7 @@ The format is based on [Keep a Changelog](https://keepachangelog.com/en/1.0.0/).
 
 ## [Unreleased]
 ### Added
+- Mute and solo toggles for instruments ([#168][i168])
 - Compressor displays threshold and invgain in dB
 - Dragging mouse to select rectangles in the tables
 - The standalone tracker can open a MIDI port for receiving MIDI notes
@@ -265,4 +266,5 @@ The format is based on [Keep a Changelog](https://keepachangelog.com/en/1.0.0/).
 [i158]: https://github.com/vsariola/sointu/issues/158
 [i160]: https://github.com/vsariola/sointu/issues/160
 [i162]: https://github.com/vsariola/sointu/issues/162
-[i166]: https://github.com/vsariola/sointu/issues/166
\ No newline at end of file
+[i166]: https://github.com/vsariola/sointu/issues/166
+[i168]: https://github.com/vsariola/sointu/issues/168
\ No newline at end of file
diff --git a/patch.go b/patch.go
index a51c0f2..cca1fbd 100644
--- a/patch.go
+++ b/patch.go
@@ -18,6 +18,7 @@ type (
 		Comment   string `yaml:",omitempty"`
 		NumVoices int
 		Units     []Unit
+		Mute      bool `yaml:",omitempty"` // Mute is only used in the tracker for soloing/muting instruments; the compiled player ignores this field
 	}
 
 	// Unit is e.g. a filter, oscillator, envelope and its parameters
@@ -352,7 +353,7 @@ func (instr *Instrument) Copy() Instrument {
 	for i, u := range instr.Units {
 		units[i] = u.Copy()
 	}
-	return Instrument{Name: instr.Name, Comment: instr.Comment, NumVoices: instr.NumVoices, Units: units}
+	return Instrument{Name: instr.Name, Comment: instr.Comment, NumVoices: instr.NumVoices, Units: units, Mute: instr.Mute}
 }
 
 // Copy makes a deep copy of a Patch.
diff --git a/tracker/bool.go b/tracker/bool.go
index f050e20..b663cd3 100644
--- a/tracker/bool.go
+++ b/tracker/bool.go
@@ -22,6 +22,8 @@ type (
 	UnitDisabled    Model
 	LoopToggle      Model
 	UniquePatterns  Model
+	Mute            Model
+	Solo            Model
 )
 
 func (v Bool) Toggle() {
@@ -47,6 +49,8 @@ func (m *Model) UnitSearching() *UnitSearching     { return (*UnitSearching)(m)
 func (m *Model) UnitDisabled() *UnitDisabled       { return (*UnitDisabled)(m) }
 func (m *Model) LoopToggle() *LoopToggle           { return (*LoopToggle)(m) }
 func (m *Model) UniquePatterns() *UniquePatterns   { return (*UniquePatterns)(m) }
+func (m *Model) Mute() *Mute                       { return (*Mute)(m) }
+func (m *Model) Solo() *Solo                       { return (*Solo)(m) }
 
 // Panic methods
 
@@ -194,3 +198,53 @@ func (m *UniquePatterns) Bool() Bool        { return Bool{m} }
 func (m *UniquePatterns) Value() bool       { return m.uniquePatterns }
 func (m *UniquePatterns) setValue(val bool) { m.uniquePatterns = val }
 func (m *UniquePatterns) Enabled() bool     { return true }
+
+// Mute methods
+
+func (m *Mute) Bool() Bool { return Bool{m} }
+func (m *Mute) Value() bool {
+	if m.d.InstrIndex < 0 || m.d.InstrIndex >= len(m.d.Song.Patch) {
+		return false
+	}
+	return m.d.Song.Patch[m.d.InstrIndex].Mute
+}
+func (m *Mute) setValue(val bool) {
+	if m.d.InstrIndex < 0 || m.d.InstrIndex >= len(m.d.Song.Patch) {
+		return
+	}
+	defer (*Model)(m).change("Mute", PatchChange, MinorChange)()
+	m.d.Song.Patch[m.d.InstrIndex].Mute = val
+}
+func (m *Mute) Enabled() bool { return m.d.InstrIndex >= 0 && m.d.InstrIndex < len(m.d.Song.Patch) }
+
+// Solo methods
+
+func (m *Solo) Bool() Bool { return Bool{m} }
+func (m *Solo) Value() bool {
+	if m.d.InstrIndex < 0 || m.d.InstrIndex >= len(m.d.Song.Patch) {
+		return false
+	}
+	for i := range m.d.Song.Patch {
+		if i == m.d.InstrIndex {
+			continue
+		}
+		if !m.d.Song.Patch[i].Mute {
+			return false
+		}
+	}
+	return !m.d.Song.Patch[m.d.InstrIndex].Mute
+}
+func (m *Solo) setValue(val bool) {
+	if m.d.InstrIndex < 0 || m.d.InstrIndex >= len(m.d.Song.Patch) {
+		return
+	}
+	defer (*Model)(m).change("Solo", PatchChange, MinorChange)()
+	for i := range m.d.Song.Patch {
+		if i == m.d.InstrIndex {
+			continue
+		}
+		m.d.Song.Patch[i].Mute = val
+	}
+	m.d.Song.Patch[m.d.InstrIndex].Mute = false
+}
+func (m *Solo) Enabled() bool { return m.d.InstrIndex >= 0 && m.d.InstrIndex < len(m.d.Song.Patch) }
diff --git a/tracker/gioui/instrument_editor.go b/tracker/gioui/instrument_editor.go
index 3dfea45..df06017 100644
--- a/tracker/gioui/instrument_editor.go
+++ b/tracker/gioui/instrument_editor.go
@@ -33,6 +33,8 @@ type InstrumentEditor struct {
 	addUnitBtn          *ActionClickable
 	presetMenuBtn       *TipClickable
 	commentExpandBtn    *BoolClickable
+	soloBtn             *BoolClickable
+	muteBtn             *BoolClickable
 	commentEditor       *Editor
 	commentString       tracker.String
 	nameEditor          *Editor
@@ -51,6 +53,8 @@ type InstrumentEditor struct {
 	expandCommentHint       string
 	collapseCommentHint     string
 	deleteInstrumentHint    string
+	muteHint, unmuteHint    string
+	soloHint, unsoloHint    string
 }
 
 func NewInstrumentEditor(model *tracker.Model) *InstrumentEditor {
@@ -64,6 +68,8 @@ func NewInstrumentEditor(model *tracker.Model) *InstrumentEditor {
 		addUnitBtn:          NewActionClickable(model.AddUnit(false)),
 		commentExpandBtn:    NewBoolClickable(model.CommentExpanded().Bool()),
 		presetMenuBtn:       new(TipClickable),
+		soloBtn:             NewBoolClickable(model.Solo().Bool()),
+		muteBtn:             NewBoolClickable(model.Mute().Bool()),
 		commentEditor:       NewEditor(widget.Editor{}),
 		nameEditor:          NewEditor(widget.Editor{SingleLine: true, Submit: true, Alignment: text.Middle}),
 		searchEditor:        NewEditor(widget.Editor{SingleLine: true, Submit: true, Alignment: text.Start}),
@@ -85,6 +91,10 @@ func NewInstrumentEditor(model *tracker.Model) *InstrumentEditor {
 	ret.expandCommentHint = makeHint("Expand comment", " (%s)", "CommentExpandedToggle")
 	ret.collapseCommentHint = makeHint("Collapse comment", " (%s)", "CommentExpandedToggle")
 	ret.deleteInstrumentHint = makeHint("Delete\ninstrument", "\n(%s)", "DeleteInstrument")
+	ret.muteHint = makeHint("Mute", " (%s)", "MuteToggle")
+	ret.unmuteHint = makeHint("Unmute", " (%s)", "MuteToggle")
+	ret.soloHint = makeHint("Solo", " (%s)", "SoloToggle")
+	ret.unsoloHint = makeHint("Unsolo", " (%s)", "SoloToggle")
 	return ret
 }
 
@@ -163,6 +173,8 @@ func (ie *InstrumentEditor) layoutInstrumentHeader(gtx C, t *Tracker) D {
 		saveInstrumentBtnStyle := TipIcon(t.Theme, ie.saveInstrumentBtn, icons.ContentSave, "Save instrument")
 		loadInstrumentBtnStyle := TipIcon(t.Theme, ie.loadInstrumentBtn, icons.FileFolderOpen, "Load instrument")
 		deleteInstrumentBtnStyle := ActionIcon(gtx, t.Theme, ie.deleteInstrumentBtn, icons.ActionDelete, ie.deleteInstrumentHint)
+		soloBtnStyle := ToggleIcon(gtx, t.Theme, ie.soloBtn, icons.SocialGroup, icons.SocialPerson, ie.soloHint, ie.unsoloHint)
+		muteBtnStyle := ToggleIcon(gtx, t.Theme, ie.muteBtn, icons.AVVolumeUp, icons.AVVolumeOff, ie.muteHint, ie.unmuteHint)
 
 		m := PopupMenu(&ie.presetMenu, t.Theme.Shaper)
 
@@ -199,6 +211,8 @@ func (ie *InstrumentEditor) layoutInstrumentHeader(gtx C, t *Tracker) D {
 				}),
 				layout.Flexed(1, func(gtx C) D { return layout.Dimensions{Size: gtx.Constraints.Min} }),
 				layout.Rigid(commentExpandBtnStyle.Layout),
+				layout.Rigid(soloBtnStyle.Layout),
+				layout.Rigid(muteBtnStyle.Layout),
 				layout.Rigid(func(gtx C) D {
 					//defer op.Offset(image.Point{}).Push(gtx.Ops).Pop()
 					dims := presetMenuBtnStyle.Layout(gtx)
@@ -249,7 +263,7 @@ func (ie *InstrumentEditor) layoutInstrumentList(gtx C, t *Tracker) D {
 		gtx.Constraints.Min.X = gtx.Dp(unit.Dp(30))
 		grabhandle := LabelStyle{Text: strconv.Itoa(i + 1), ShadeColor: black, Color: mediumEmphasisTextColor, FontSize: unit.Sp(10), Alignment: layout.Center, Shaper: t.Theme.Shaper}
 		label := func(gtx C) D {
-			name, level, ok := (*tracker.Instruments)(t.Model).Item(i)
+			name, level, mute, ok := (*tracker.Instruments)(t.Model).Item(i)
 			if !ok {
 				labelStyle := LabelStyle{Text: "", ShadeColor: black, Color: white, FontSize: unit.Sp(12), Shaper: t.Theme.Shaper}
 				return layout.Center.Layout(gtx, labelStyle.Layout)
@@ -266,6 +280,10 @@ func (ie *InstrumentEditor) layoutInstrumentList(gtx C, t *Tracker) D {
 				style.HintColor = instrumentNameHintColor
 				style.TextSize = unit.Sp(12)
 				style.Font = labelDefaultFont
+				if mute {
+					style.Color = disabledTextColor
+					style.Font.Style = font.Italic
+				}
 				dims := layout.Center.Layout(gtx, func(gtx C) D {
 					defer clip.Rect(image.Rect(0, 0, gtx.Constraints.Max.X, gtx.Constraints.Max.Y)).Push(gtx.Ops).Pop()
 					return style.Layout(gtx)
@@ -277,6 +295,10 @@ func (ie *InstrumentEditor) layoutInstrumentList(gtx C, t *Tracker) D {
 				name = "Instr"
 			}
 			labelStyle := LabelStyle{Text: name, ShadeColor: black, Color: color, Font: labelDefaultFont, FontSize: unit.Sp(12), Shaper: t.Theme.Shaper}
+			if mute {
+				labelStyle.Color = disabledTextColor
+				labelStyle.Font.Style = font.Italic
+			}
 			return layout.Center.Layout(gtx, labelStyle.Layout)
 		}
 		return layout.Inset{Left: unit.Dp(6), Right: unit.Dp(6), Top: unit.Dp(4)}.Layout(gtx, func(gtx C) D {
diff --git a/tracker/gioui/keybindings.yml b/tracker/gioui/keybindings.yml
index f8732f8..d570721 100644
--- a/tracker/gioui/keybindings.yml
+++ b/tracker/gioui/keybindings.yml
@@ -8,6 +8,8 @@
 - {key: "L", shortcut: true, action: "LoopToggle"}
 - {key: "N", shortcut: true, action: "NewSong"}
 - {key: "S", shortcut: true, action: "SaveSong"}
+- {key: "M", shortcut: true, action: "MuteToggle"}
+- {key: ",", shortcut: true, action: "SoloToggle"}
 - {key: "O", shortcut: true, action: "OpenSong"}
 - {key: "I", shortcut: true, shift: true, action: "DeleteInstrument"}
 - {key: "I", shortcut: true, action: "AddInstrument"}
diff --git a/tracker/gioui/keyevent.go b/tracker/gioui/keyevent.go
index 737e66b..cdce2f1 100644
--- a/tracker/gioui/keyevent.go
+++ b/tracker/gioui/keyevent.go
@@ -222,6 +222,10 @@ func (t *Tracker) KeyEvent(e key.Event, gtx C) {
 		t.LoopToggle().Bool().Toggle()
 	case "UniquePatternsToggle":
 		t.UniquePatterns().Bool().Toggle()
+	case "MuteToggle":
+		t.Mute().Bool().Toggle()
+	case "SoloToggle":
+		t.Solo().Bool().Toggle()
 	// Integers
 	case "InstrumentVoicesAdd":
 		t.Model.InstrumentVoices().Int().Add(1)
diff --git a/tracker/gioui/unit_editor.go b/tracker/gioui/unit_editor.go
index 1bb279e..2e0de2f 100644
--- a/tracker/gioui/unit_editor.go
+++ b/tracker/gioui/unit_editor.go
@@ -319,7 +319,7 @@ func (p ParameterStyle) Layout(gtx C) D {
 				instrItems := make([]MenuItem, p.tracker.Instruments().Count())
 				for i := range instrItems {
 					i := i
-					name, _, _ := p.tracker.Instruments().Item(i)
+					name, _, _, _ := p.tracker.Instruments().Item(i)
 					instrItems[i].Text = name
 					instrItems[i].IconBytes = icons.NavigationChevronRight
 					instrItems[i].Doer = tracker.Allow(func() {
diff --git a/tracker/list.go b/tracker/list.go
index a39d65c..a970101 100644
--- a/tracker/list.go
+++ b/tracker/list.go
@@ -168,11 +168,12 @@ func (v *Instruments) List() List {
 	return List{v}
 }
 
-func (v *Instruments) Item(i int) (name string, maxLevel float32, ok bool) {
+func (v *Instruments) Item(i int) (name string, maxLevel float32, mute bool, ok bool) {
 	if i < 0 || i >= len(v.d.Song.Patch) {
-		return "", 0, false
+		return "", 0, false, false
 	}
 	name = v.d.Song.Patch[i].Name
+	mute = v.d.Song.Patch[i].Mute
 	start := v.d.Song.Patch.FirstVoiceForInstrument(i)
 	end := start + v.d.Song.Patch[i].NumVoices
 	if end >= vm.MAX_VOICES {
diff --git a/tracker/player.go b/tracker/player.go
index f444632..b512af6 100644
--- a/tracker/player.go
+++ b/tracker/player.go
@@ -331,6 +331,15 @@ func (p *Player) compileOrUpdateSynth() {
 			return
 		}
 	}
+	voice := 0
+	for _, instr := range p.song.Patch {
+		if instr.Mute {
+			for j := 0; j < instr.NumVoices; j++ {
+				p.synth.Release(voice + j)
+			}
+		}
+		voice += instr.NumVoices
+	}
 }
 
 // all sends from player are always non-blocking, to ensure that the player thread cannot end up in a dead-lock
@@ -387,11 +396,13 @@ func (p *Player) trigger(voiceStart, voiceEnd int, note byte, ID int) {
 			age = p.voices[i].samplesSinceEvent
 		}
 	}
+	instrIndex, err := p.song.Patch.InstrumentForVoice(oldestVoice)
+	if err != nil || p.song.Patch[instrIndex].Mute {
+		return
+	}
 	p.voices[oldestVoice] = voice{noteID: ID, sustain: true, samplesSinceEvent: 0}
 	p.voiceLevels[oldestVoice] = 1.0
-	if p.synth != nil {
-		p.synth.Trigger(oldestVoice, note)
-	}
+	p.synth.Trigger(oldestVoice, note)
 }
 
 func (p *Player) release(ID int) {